Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of the exposure. Such a postexposure anxiogenic effect depended upon melanopsin-based intrinsically photosensitive retinal ganglion cell (ipRGC) activities rather than rod/cone photoreceptor inputs. Chemogenetic manipulation of…
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Day: March 22, 2023
Ultrasound Combined With Single-Use Cervical Dilation Sticks And Lidocaine Achieved Good Clinical Outcomes In Hysteroscopic Removal Of The Intrauterine Device: A Pilot Study by Yini Zhao
CONCLUSIONS: In hysteroscopic IUD removal, ultrasound combined with single-use cervical dilation sticks and lidocaine can gently soften and dilate the cervix in a short time, shortening the procedure time and reducing pain. The procedure is simplified, rapid, safe and has a high success rate.
The frequency of psychiatric disorder co-morbidities in patients with fibromyalgia: A cross-sectional study in Iran by Sara Sadr
AIM: This study aimed to investigate psychiatric disorders in Iranian female patients with fibromyalgia (FM).
Mental health care before and during the COVID-19 pandemic in public healthcare centers of a Chilean municipality by Soledad Andrea San Martín
CONCLUSIONS: It is a priority for Chile to increase coverage in primary mental health care. The data provided in this study show at an exploratory level that the initial situation of the pandemic could have affected access to timely care for the most vulnerable people with mental disorders.
Internet, studying and daily rhythm: health symptoms among higher education students by Hanna Rouvinen
CONCLUSIONS: The findings suggest that problems of studying and daily rhythm and spending more time online are related to health symptoms among the students. The study’s findings can be used from a prevention standpoint for early identification and further to identify the need for seeking professional treatment.
Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesis by Alejandro de Janon
Hematoimmunopoiesis takes place in the adult human bone marrow (BM), which is composed of heterogeneous niches with complex architecture that enables tight regulation of homeostatic and stress responses. There is a paucity of representative culture systems that recapitulate the heterogeneous three-dimensional (3D) human BM microenvironment and that can endogenously produce soluble factors and extracellular matrix…
PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction by Yuxin Wang
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme responsible for lipid metabolism and is a promising drug target. Here, we report the first-in-class PROTAC small-molecule degraders of sEH. Our optimized PROTAC selectively targets the degradation of cytosolic but not peroxisomal sEH, resulting in exquisite spatiotemporal control. Remarkably, our sEH PROTAC molecule has higher potency in…
HIGH CONCENTRATIONS OF FRUCTOSE CAUSE BRAIN DAMAGE IN MICE by Anderson Cargnin-Carvalho
Excessive fructose consumption is associated with the incidence of obesity and systemic inflammation, resulting in increased oxidative stress and damage to the function of brain structures. Thus, we hypothesized that fructose consumption will significantly increase inflammation, oxidative damage and mitochondrial dysfunction in the mouse brain and, consequently, memory damage. The effects of different fructose concentrations…
Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases by Halimulati Abuduwaili
The quality of skeletal muscle is maintained by a balance between protein biosynthesis and degradation. Disruption in this balance results in sarcopenia. However, its underlying mechanisms remain under-investigated. Selenoprotein P (SeP; encoded by Selenop in mice) is a hepatokine that is upregulated in type 2 diabetes and aging and causes signal resistances via reductive stress.…
NARINGIN PREVENTS DIABETIC NEPHROPATHY IN RATS THROUGH BLOCKAGE OF OXIDATIVE STRESS AND ATTENUATION OF THE MITOCHONDRIAL DYSFUNCTION by Adriana Pérez
We have studied the effects of naringin (NAR), a flavonoid from citric fruits, on morphology, ultrastructure and function of the kidney in streptozotocin (STZ)-induced diabetic rats. Two groups of animals were used: 1) control rats, and 2) STZ rats (60 mg STZ/kg b.w.). At 3 days after induction, one group of STZ-treated rats received 40…
Effect of delivery mode on postnatal platelet count dynamics in neonates born to mothers with immune thrombocytopenia by Shoichiro Wada
We aimed to determine the effect of delivery mode on postnatal platelet count dynamics in neonates born to mothers with immune thrombocytopenia (ITP). This single-center, retrospective study included 41 mothers with ITP and their 65 infants born by vaginal delivery (VD, n = 30) and cesarean section (CS, n = 35) between January 1997 and…
Feeding practices, dietary adequacy, and dietary diversities among caregivers with under-five children: A descriptive cross-section study in Dodoma region, Tanzania by Walter C Millanzi
CONCLUSION: Under-five children are at serious risk of nutritional problems as most caregivers in this study demonstrated unsatisfactory feeding practices on dietary diversities for dietary adequacy below the world health organization recommended Minimum Dietary diversity and Minimum Meal Frequency. Community-based nutritional education programs for caregivers need to be disseminated to the community level to address…